The Pro iCAN/Pro iCAN Signature is inherently balanced and offers only a single pair of balanced channels, optimised for sound quality. Having multiple independent headphone outputs means essentially having two fully separate amplifiers.
Some low-end headphone amplifiers are built like this with four, or even eight separate headphone channels. If using multiple Pro iCAN/Pro iCAN Signature is not possible (expense, etc), individual headphone amplifiers per musician are recommended.
The intention of the Pro iCAN/Pro iCAN Signature is to offer the recording/mastering engineer (or the audiophile) an ultimate monitor system using headphones while providing an experience akin to large monitor speakers or indeed to drive these speakers (or both).